Monday, June 29, 2009

The Mosquito, Revised

http://www.newsweek.com/id/204228


Aedes Aegypti is a tricky enemy with a dangerous weakness for travel. Unlike other mosquitoes, it can survive the cold and thrives on city life. The increase of international trade and the accelerating pace of urbanization have broadened its horizon with grim consequences. The disease it carries, dengue fever—debilitating and sometimes lethal—is spreading fast. More than 100 million people in 100 countries are afflicted every year. Fatality rates can top 20 percent. There is no vaccine, no cure and no solution—none, at least, that conventional medicine can offer.

A new strategy involves a subtle reconfiguring of the bug's DNA. Scientists working in labs near Oxford have devised a genetic modification that sterilizes the male Aedes, transforming the critter into his own worst enemy. He can still mate—but he can't breed. Any offspring dies before becoming fully developed. The idea is to release a huge, all-conquering swarm of the doctored insects into the wild, let them find partners among the native females and wait for the mosquito population to decline. Preliminary trials, looking at both safety and effectiveness, have already taken place in Malaysia. Within a few years, the Franken-insects could be airborne.

The idea of GM mosquitoes was first floated 20 years ago. But it's only recently gained the support of mainstream health officials. The Bill and Melinda Gates Foundation has invested $38 million into the research. In May, experts from around the world gathered